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KMID : 1161420220250050523
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Journal of Medicinal Food
2022 Volume.25 No. 5 p.523 ~ p.528
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Effects of Golden Thistle (Scolymus hispanicus L.) on Cytotoxic Activity: Cell Cycle Arrest and Apoptotic Properties on the CaCo-2 Cell Line
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Ozel-Tasci Cansu
Gulec Sukru
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Abstract
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Cancer is a global concern for many individuals with high mortality rates, with colon cancer being the third most common diagnosed cancer worldwide. A phytochemical-rich diet is often recommended in the prevention and during the treatment of cancer cases. Golden thistle (GT) plant (Scolymus hispanicus L.) is a wild edible plant widely consumed in the Mediterranean countries. In this study, we aimed to obtain a hydromethanolic extract from three parts of the GT plant and test its antiproliferative activity in the CaCo-2 human adenocarcinoma cell line. Concentrations of the golden thistle extract (GTE) were used to treat CaCo-2 cells and the most significant reduction was detected with 4?mg/mL GTE after 72?h, with 78.3% decrease in cell viability (P?
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KEYWORD
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apoptosis, Asteraceae, cell cycle arrest, colon cancer, golden thistle, Scolymus hispanicus L.
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